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. Author manuscript; available in PMC: 2007 Jan 3.
Published in final edited form as: Neurology. 2005 Feb 8;64(3):501–508. doi: 10.1212/01.WNL.0000150885.00929.7E

Table 2.

Areas of significantly greater brain response during encoding of novel vs repeated pictures in nondemented older adults

Brain region Subregion Volume, mm3 Coordinates* of maximum intensity voxel Eta2 for encode vs repeat
APOE ε4 group
 R fusiform gyrus BA 19 119,552 38R, 65P, 8I  0.93
 L precuneus BA 7  10,368 2L, 69P, 40S  0.83
 L superior frontal gyrus L middle frontal gyrus  5,248 30L, 11A, 48S 0.94
 L middle frontal gyrus BA 46  3,008 46L, 35A, 16S 0.70
 R medial frontal gyrus BA 8/R cingulate gyrus  2,944 2R, 27A, 40S  0.71
 R red nucleus R thalamus  2,816 2R, 25P, 4I   0.74
 L paracentral lobule/BA 6 BA 4  2,816 2L, 33P, 60S  0.67
 R superior temporal gyrus BA 21  1,216 54R, 7A, 12I  0.56
 R cingulate gyrus BA 24   960 10R, 17P, 36S 0.56
APOE ε3 group
 L middle occipital gyrus BA 18  14,016 26L, 81P, 0I  0.81
 R middle occipital gyrus BA 19  6,656 30R, 65P, 4S  0.76
 L caudate tail L cingulate gyrus  3,712 22L, 41P, 20S 0.74
 L medial frontal gyrus BA 10/L superior frontal gyrus  3,200 2L, 67A, 4I   0.79
 R inferior frontal gyrus BA 46  1,408 38R, 35A, 4S  0.70
 R cingulate gyrus R posterior cingulate  1,088 14R, 41P, 24S 0.68
 L caudate L parahippocampal gyrus/L hippocampus  1,024 34L, 37P, 0I  0.71
 R caudate R caudate tail   896 22R, 33P, 16S 0.64
*

From Talairach and Tournoux.25

BA = Brodmann area; P = posterior; I = inferior; S = superior; A = anterior.