Table 1.
Summary of disease induced by transfer of CD4 or CD25− CD44lo CD4 T cells into Rag2−/− mice
| Cells | Macrophage/eosinophil pneumonia | Eosinophilic gastritis | Eosinophilic esophagitis | Liver inflammation | Colitis | Mesenteric lymph node granuloma |
|---|---|---|---|---|---|---|
| 30,000 CD25− CD44lo cells | 13/13 | 13/13 | 5/8 | 8/8 | 4/13 | 7/13 |
| 30,000 CD4 cells | 7/7 | 4/7 | 1/7 | 5/7 | 5/7 | 3/7 |
| 2 million CD25− CD44lo cells | 3/6 | 4/6 | 3/6 | 2/6 | 0/6 | 0/6 |
| 2 million CD4 cells | 0/7 | 0/7 | 0/7 | 0/7 | 0/7 | 0/7 |
| AND 30,000 CD4 cells | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 |
| AND 2 million CD4 cells | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 | 0/3 |
Shown are results from three or more separate experiments for each group, with pathology determined at least 4 months after transfer.