Fig. 1.

Cortical regions exhibiting activity differences and similarities during past and future thought. (A–D) Percent signal change for representative regions from Table 1 showing a significant interaction such that imagining of future events (SF) led to greater activation over the 10-modeled timepoints than did recollecting oneself in the past (SR). Both self-related tasks also led to greater activity than a control task involving imagery of another person participating in similar events (CI). Regions listed in Table 1 but not shown here demonstrate patterns similar to those shown in the figure. (E–H) Percent signal change for selected regions from Table 2 showing a statistically indistinguishable pattern of activity across time while subjects envisioned their personal future (SF) and recollected the past (SR) in response to a series of event cues (e.g., Birthday). Imagining a familiar individual in similar scenarios (CI) resulted in a pattern of activity different from both the past and future tasks. Regions listed in Table 2 but not shown here demonstrate patterns similar to those shown in the figure.