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. 2000 Nov 28;97(25):13591–13596. doi: 10.1073/pnas.250491997

Figure 1.

Figure 1

Outline of the Taxol biosynthetic pathway. The cyclization of geranylgeranyl diphosphate to taxadiene by taxadiene synthase and the hydroxylation to taxadien-5α-ol by taxadiene 5α-hydroxylase (a), the acetylation of taxadien-5α-ol by taxa-4(20),11(12)-dien-5α-ol O-acetyltransferase (TAT) (b), the conversion of a 2-debenzoyl “taxoid-type” intermediate to 10-deacetylbaccatin III by a taxane 2α-O-benzoyltransferase (TBT) (c), the conversion of 10-deacetylbaccatin III to baccatin III by 10-deacetylbaccatin III 10-O-acetyltransferase (DBAT) (d), and the side-chain attachment to baccatin III to form Taxol (e) are illustrated. The broken arrow indicates several as-yet-undefined steps.