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Outline of the synthesis and utilization of 2-debenzoyl-7,13-diacetylbaccatin III. Step a, methylene chloride, acetic anhydride, 4-(N,N′-dimethylamino)pyridine, triethylamine, 25°C, 18 h. Step b, tetrahydrofuran, bis(2-methoxyethoxy)aluminum hydride (>65% in toluene), 0°C, 30 min. Step c indicates the reaction catalyzed by taxane 2α-O-benzoyltransferase in the presence of benzoyl-CoA.
