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Effect of modulating wild-type huntingtin levels on survival in YAC128 mice.
| Sex | Genotype | Deaths | Total Mice | Percent Surviving |
| Males | WT | 4 | 46 | 91% |
| YAC18/128 | 3 | 11 | 73% | |
| YAC128 | 12 | 48 | 75% | |
| YAC128-/- | 11 | 15 | 27% | |
| Females | WT | 5 | 42 | 88% |
| YAC18/128 | 0 | 4 | 100% | |
| YAC128 | 5 | 66 | 92% | |
| YAC128-/- | 3 | 19 | 84% | |
YAC128-/- mice express mutant htt and no wild-type htt. YAC128 mice express mutant htt and 2 copies of wild-type htt. YAC18/128 express mutant htt and increased levels of wild-type htt.
