Table 2.

Effect of over-expression of wild-type huntingtin on HD-like phenotypes in the YAC128 mouse model of HD.

Phenotype	Percent Difference YAC128 Compared to WT	Percent Difference YAC18/128 Compared to WT	Percent Rescue with WT htt Expression	Significance
Rotarod	-36%	-41%	None	p = 0.5
Activity – 2 Months	+6%	+2%	74%	P = 0.5
Activity – 12 Months	-10%	-6%	47%	P = 0.5
Striatal Volume	-9%	-7%	21%	p = 0.3
Striatal Neuronal Counts	-6%	-3%	38%	p = 0.4
Striatal DARPP-32 Expression	-18%	-14%	22%	p = 0.3
Striatal Neuronal Size	-12%	-2%	87%	p < 0.001