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Schematic diagram summarizing the roles of LPA, S1P, RhoGTPases, and MT1-MMP in tumor migration and invasion of collagen matrices. LPA stimulates tumor cells migration while S1P inhibits migration of most tumor types on 2D matrix substrates. Lipid-induced invasion of 3D collagen matrices, but not migration, requires MT1-MMP. Only tumor cell invasion of 3D matrices is blocked by MMP inhibitors.
