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. 2006 Dec 12;6:107. doi: 10.1186/1471-2148-6-107

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Copyright © 2006 Karboul et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Distribution of the three PGRS types through sSNP-based genetic clusters and PGG groups. The Phylogenetic tree of M. tuberculosis isolates from New York and New Jersey shows the relative distribution of PGRS types 1 (PGRST1; +/-), 2 (PGRST2; +/+), and 3 (PGRST3; -/-) with respect to the synonymous single-nucleotide (sSNP)-defined 9 major genetic clusters (I, II, IIA, and III to VIII) and PGG grouping. The 36 sSNP-based phylogenetic tree was constructed as described by Gutacker et al. [33]. The data clearly indicate that the PE_PGRS17/PE_PGRS18-associated gene conversion event occurs multiple times mainly in PGG2 strains.