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. 2006 Dec 5;3(12):e484. doi: 10.1371/journal.pmed.0030484

Figure 1. Persistent Depletion of CD4+ T cells in the GI Tract despite Normalization in the Peripheral Blood.

Figure 1

PBMCs and MMCs from 54 patients with AEI and 18 HIV-1–uninfected control participants were analyzed by flow cytometry. CD3+ gated lymphocytes were analyzed for the expression of CD4 and CD8.

(A) Representative flow plots from patient 336 are depicted. CD8+ T cells are shown on the x-axis and CD4+ T cells on the y-axis.

(B) A box plot depicting the comparison between CD4+ T cells derived from the blood and GI tract of 22 patients examined cross sectionally. The percentages of CD4+ T cells in the blood (white) and GI tract (grey) are compared between HIV-uninfected, AEI-untreated, and AEI groups treated for up to 1 y, 1–3 y, and 3–7 y, respectively. In these plots, the boxes extend from the first to the third quartiles, enclosing the middle 50% of the data. The middle line within each box indicates the median of the data, whereas the vertical line extends from the 10th to the 90th percentile. Means of the data are represented by filled-in squares.

(C) Comparisons between the blood and GI tract of 18 patients followed longitudinally after initiation of antiretroviral therapy. The percentages of CD4+ T cells in the blood (grey) and GI tract (black) at baseline (AEI-untreated) and following treatment are depicted per study patient.

(D) Cumulative data from the 18 patients followed longitudinally where the percentages of CD4+ T cells in the blood (white) and GI tract (grey) are compared after 1 y, 2 y, and 3 y of HAART.