Figure 2.

Deuterium content vs. time for deuterated monomer (●), corrected deuterated monomer (⧫), deuterated fibrils (■), and corrected deuterated fibrils (▴). The data presented in corrected deuterated monomer and fibril curves have been adjusted to remove contributions from side-chain protons (see text). (a) Magnified view of the first 42-min segment from c. (b) Magnified view of the 0- to 21-h segment from c. (c) HX kinetics data for monomer (792 h) and fibrils (1135 h). The kinetic plots presented here are averaged from data on three monomer samples and four fibril samples. The error bars in b and c represent the standard deviation of the mean and in some cases are equal to or smaller than the size of the symbol. a represents single kinetic runs at each time point.