Table 3. susceptibility loci in B6 mice, and transcripts of genes encoded in these genomic regions that are differentially expressed between T. cruzi- infected B6 and F1 mice.

Chromosomal marker	single-pointa		multi-pointa		differentially expressed transcriptsb
	χ2	p-value	χ2	p-value	gene symbol	mean SLRb
Chromosome 5
d5mit20	15,52	4,08E-05	14,34	7,63E-05
d5mit155	14,78	6,04E-05	15,06	5,21E-05
d5mit157	16,00	3,17E-05	15,06	5,21E-05
d5mit10	18,65	7,85E-06	19,06	6,33E-06	Cxcl11	−1.6
d5mit41	16,75	2,13E-05	18,28	9,53E-06	Bmp2k	−1.4
d5mit403	17,52	1,42E-05	18,28	9,53E-06	Opn/Spp1/Eta-1	+1.7
d5mit239	16,25	2,78E-05	16,25	2,78E-05
d5mit240	16,00	3,17E-05	16,25	2,78E-05
d5mit25	18,06	1,07E-05	18,28	9,53E-06
Chromosome 13
d13mit148a	10,56	5,78E-04	9,62	9,65E-04
d13mit76a	12,55	1,98E-04	12,55	1,98E-04
d13mit230	12,25	2,33E-04	12,55	1,98E-04
d13mit262	10,90	4,81E-04	10,88	4,86E-04
d13mit151	6,00	7,15E-03	10,88	4,86E-04
d13mit77	11,95	2,73E-04	11,88	2,84E-04
MM13BM1	10,25	6,83E-04	13,64	1,11E-04
MM13BM2	12,94	1,61E-04	14,34	7,62E-05
d13mit35	13,64	1,11E-04	12,55	1,98E-04
Chromosome 17
d17mit173	20,08	3,71E-06	20,43	3,09E-06
d17mit30	20,43	3,09E-06	20,43	3,09E-06
d17mit198	19,64	4,67E-06	20,43	3,09E-06
d17mit135	22,70	9,47E-07	22,70	9,47E-07	H2-Ea	−7.9
d17mit16	21,88	1,45E-06	22,70	9,47E-07	Msh5	−1.9
d17mit234	21,06	2,23E-06	22,70	9,47E-07	Ng23	−3.1
d17mit11	18,46	8,68E-06	22,70	9,47E-07	H2-D1	−7.6
d17mit168	16,52	2,41E-05	20,43	3,09E-06	Tubb5	−0.8
d17mit50	18,28	9,53E-06	18,28	9,53E-06

^aSingle-point and multi-point calculations of χ² for microsatellite markers typed in 68 susceptible B6xF1 backcross mice. χ² and p values refer to a one-sided test for homozygosity

^bDifferentially expressed genes (derived from microarray analysis, see tables 1 and 2) in line with approximate genomic localisation; SLR, signal log ratio, log₂. Differential expression was confirmed by an independent analysis, see text