Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Dec 20;1(1):e66. doi: 10.1371/journal.pone.0000066

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Carmena et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Summary of physical interactions and working model.

(A) Diagram summarizing the physical interactions between Cno and Nintra, Ras^Act and Dsh.

(B) Working model.

The modulation of the information conveyed by three signaling pathways, Wg, N and Ras-MAPK, is critical for muscle progenitor specification.

Our data show that Cno interacts physically and genetically with these three pathways, negatively regulating the information flow to key progenitor transcriptional targets, L'sc and Eve.

In this model, the Cno/Dsh interaction is pivotal to modulate signaling thresholds.

Cno/Dsh interaction facilitates the release of Cno repression on Ras^Act signaling and the inhibition of N signaling by Cno. Dsh recruitment by Cno leads to canonical Wg signal inhibition. Arr, Arrow; Fz2, Frizzled2.