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. 2006 Dec 27;1(1):e124. doi: 10.1371/journal.pone.0000124

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Roato et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The addition of both OPG and anti-TNF-α caused a dose-dependent inhibition of IL-7-induced osteoclastogenesis. The anti-TNF-α antibody caused a strong osteoclastogenesis inhibition, about 90% (A) while OPG caused a 50% inhibition (B).