Figure 6.

Imatinib mesylate does not block serum-induced contraction of tethered collagen gels. The ability of fibroblasts to contract tethered collagen lattices was assessed. Cells were seeded into tethered collagen gels. Mechanical tension was generated throughout a 48-hour period after which the gels were released. DMEM containing 10% FCS (C) stimulated contraction in comparison to serum-free DMEM (A) and PDGF-BB (10 ng/ml) (E). Imatinib did not affect contraction by serum-free DMEM (B), 10% FCS (D), and PDGF-BB (F). G: Quantification of gel weight after contraction. Results represent the mean ± SD. *P < 0.05.