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. 2007 Jan;170(1):263–271. doi: 10.2353/ajpath.2007.060596

Figure 2.

Figure 2

AM inhibits inflammatory response in CIA. Systemic and local expression of inflammatory mediators in untreated (control) or AM-treated CIA mice assayed at day 35 after immunization. A: Cytokine/chemokine contents in joints. A paw from a nonimmunized mouse was analyzed simultaneously for assessment of the basal response. B: Serum TNF-α and IL-1β levels. n = 6 to 8 mice per group. *P < 0.001 versus controls. C: Cytokine/chemokine production by synovial membrane cells from CIA mice activated with CII in the absence or presence of different concentrations of AM or CGRP. n = 3 experiments performed in duplicate. *P < 0.001 versus control.