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. 2007 Jan;170(1):388–698. doi: 10.2353/ajpath.2007.060708

Figure 5.

Figure 5

Vascular (A, B) and cardiac (C, D) expression of iNOS (A, C) and ICAM-1 (B, D) mRNA in aged (29 months old) rats with or without etanercept treatment (4 weeks, 1 mg/kg/week). Analysis of mRNA expression was performed by real-time QRT-PCR. Data ± SEM are normalized to the young (3 months old) mean values (n = 5 for each group). *P < 0.05 versus young, #P < 0.05 versus untreated. E: Correlation between age-related increases in TNF-α and iNOS mRNA expression in carotid arteries of wild-type mice. F: Expression of iNOS mRNA in carotid arteries of young and aged TNF+/+ mice and TNF−/− mice. Data ± SEM are normalized to the 3-month-old mean values (n = 5 to 6 for each group). *P < 0.05 versus young, #P < 0.05 versus wild type.