Figure 7.

Patterns of gene expression and modulation in kidneys of 7-week-old Col4A3^−/− mice. Shown are 395 GeneChip probe sets selected for twofold or greater variation between wild-type and untreated Col4A3^−/− (UN) groups at P < 0.01. The columns of the heat map display patterns of relative gene expression levels for individual experimental groups. Each column represents 395 normalized mean probe set signal intensity values for a single experimental group of five mice. Changes in gene expression across the experimental conditions are reflected in the color variation as shown by the color bar. Two-dimensional hierarchical clustering was performed to explore relationships (shown by the dendrogram) among the experimental groups.