Table 2.
Sex- and age-adjusted associations between asthma polymorphisms and glioblastoma multiforme (GBM) from population based Swedish case-control study (2000–2002), and comparisons with previously published associations between polymorphisms and asthma or inflammatory conditions.
| Gene (SNP) | Previous asthma literature | GBM (present study) | Previous asthma literature | ||||
|---|---|---|---|---|---|---|---|
| Asthma OR (95% CI) | GBM OR (95% CI) | GBM OR (trend test) | GBM Cases1, 2 n (%) | GBM Controls1, 2 n (%) | Asthma Cases (%) | Asthma Controls (%) | |
| IL-4RA (rs1805015, ser478pro) | Asthma (14) | Asthma (14 ) | |||||
| TT | 1.96 (1.13, 3.44) | 1.00 | 1.00 | 64 (59) | 288 (70) | 77 | 63 |
| TC | 1.00 | 1.64 (1.05, 2.55) | 1.73 | 40 (37) | 107 (26) | 20 | 33 |
| CC | 1.09 | 4 (4) | 16 (4) | 3 | 4 | ||
| p = 0.07 (trend) | |||||||
| IL-4RA (rs1801275, gln551arg) | Asthma (14) | Asthma (14) | |||||
| AA | 1.25 (0.72, 2.01) | 1.00 | 1.00 | 53 (49) | 243 (60) | 68 | 64 |
| AG | 1.00 | 1.61(1.05, 2.47) | 1.52 | 45 (41) | 236 (34) | 26 | 32 |
| GG | 2.09 | 11 (10) | 24 (6) | 5 | 4 | ||
| p = 0.02 (trend) | |||||||
| IL-13 (rs20541, arg130gln) | Asthma (16) | Asthma (16) | |||||
| GG | 0.48 (0.30, 0.76) | 1.00 | 1.00 | 74 (67) | 254 (60) | 36 | 54 |
| AG | 1.00 | 0.75 (0.48, 1.17) | 0.81 | 33 (30) | 144 (33) | 48 | 39 |
| AA | 0.41 | 3 (3) | 24 (7) | 16 | 7 | ||
| p= 0.12 (trend) | |||||||
| IL-13 (rs1800925, -1112C/T) | Asthma (17) | Asthma (17) | |||||
| CC | 0.51 (0.31, 0.84) | 1.00 | 1.00 | 84 (80) | 277 (69) | 58 | 73 |
| CT | 1.00 | 0.56 (0.33, 0.96) | 0.55 | 18 (17) | 111 (28) | 37 | 25 |
| TT | 0.64 | 3 (3) | 15 (4) | 5 | 2 | ||
| p= 0.05 (trend) | |||||||
| ADAM33 (rs2280091, T1) | Asthma (22) | Asthma (22) | |||||
| TT | 0.24 (0.15, 0.39) | 1.00 | 1.00 | 82 (77) | 297 (71) | 58 | 85 |
| TC | 1.00 | 0.82 (0.50, 1.33) | 0.85 | 24 (22) | 106 (26) | 37 | 14 |
| CC | 0.56 | 2 (1) | 13 (3) | 6 | 1 | ||
| p= 0.35 (trend) | |||||||
| COX-2 -765GC | C-reactive protein (CRP) levels (26)) 1 | CRP (26)) 3 | |||||
| GG | 173.64 | 1.00 | 1.00 | 80 (74) | 286 (72) | 75 | |
| GC | 149.57 | 0.84 (0.45, 1.57) | 0.90 | 27 (25) | 105 (26) | 24 | |
| CC | 0.52 | 1 (1) | 8 (2) | 1 | |||
| p= 0.53 (trend) | |||||||
Differences in numbers of cases and controls among polymorphisms reflect failure to identify genotype for some DNA samples.
Numbers in parentheses are percentages of genotypes for GBM cases and controls excluding people reporting physician-diagnosed asthma or hayfever.
Papafili et al. (26) do not report C-reactive protein distribution of case group.