Figure 2.

Transcription profiles support a model of HDAC function. (A) A common regulatory sequence, GGCGGCNAN, was found between 10 and 500 bp upstream of the translation start site for a subset of genes up-regulated in sin3. This sequence corresponds to the known regulatory sequence URS1, which is bound by Ume6p, a protein that recruits the Sin3p-Rpd3p corepressor complex (7). (B) Lists of genes up-regulated in the rpd3 and sin3 profiles are similar to lists of genes up-regulated in the sap30, ume6, and TSA data sets. This is consistent with the molecular model for Rpd3p function depicted in C.