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. 2000 Nov 28;97(25):13708–13713. doi: 10.1073/pnas.250477697

Figure 3.

Figure 3

Feedback inhibition modulates HDAC activity. Two genes were identified as potential modulators of RPD3- and SIR2-mediated repression: the zinc transporter gene, ZRT1, is repressed by the zinc-dependent HDAC, Rpd3p; the NAD-biosynthesis gene, BNA1, is repressed by the NAD-dependent HDAC, Sir2p (12) (B.E.B. and S.L.S., unpublished results). Interestingly, RPD3 activates BNA1, and SIR2 appears to activate ZRT1. The particular acetylation pattern induced by these HDACs may, in certain cases, activate transcription (see text and Fig. 5). Fold changes induced by RPD3 deletion, SIR2 deletion, and by 15 min and 30 min TSA treatments are shown.