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. 2000 Nov 28;97(25):13708–13713. doi: 10.1073/pnas.250477697

Figure 5.

Figure 5

RPD3 disruption represses genes near telomeric ends. (A) RPD3 deletion and histone H4 depletion both regulate genes within 15–20 kb of telomere ends. In contrast, SIR2 deletion regulates genes within 5–10 kb of these ends (13). (B) Like RPD3 deletion, TSA treatment down-regulates telomeric genes. Telomeric genes sensitive to SIR deletion (12) are repressed rapidly by TSA. Telomeric genes sensitive to H4 depletion (13) are slowly repressed by TSA. Like RPD3 deletion, TSA up-regulates histone genes. Taken together, these data support a model in which RPD3 abrogates telomeric silencing via the direct and indirect mechanisms outlined in C. (C) Rpd3p appears to activate telomeric genes directly by deacetylating histone H4 lysine 12 and, thereby, hindering repression by SIR proteins. Rpd3p appears to activate telomeric genes indirectly by repressing histone genes.