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. 2000 Nov 28;97(25):13714–13719. doi: 10.1073/pnas.240335297

Figure 1.

Figure 1

Construction of highly truncated minidystrophin genes. Dystrophin has four major domains: the N-terminal domain (N), the CR domain, the CT domain, and the central rod domain, which contains 24 rod repeats (R) and four hinges (H). The minidystrophin genes were constructed by deleting a large portion of the central rods and hinges and nearly the entire CT domain (except the last 3 aa). The minidystrophin genes subsequently were cloned between an MCK promoter (or a CMV promoter) and a poly(A) sequence in AAV vectors.