Table 1.

Multiple Sequence alignment of mammalian homologs of HBD-2.

The chosen sequences from SWISSPROT have ≥ 40% sequence identity to human defensin HBD-2; Sequence details (Swiss-Prot id:organism): BD02_HUMAN: Homo sapiens (Hum); BD02_PANTR: Pan troglodytes (Chimp); BD02_MACMU: Macaca mulatta (Monkey); BD04_RAT: Rattus norvegicus (Rat); BD03_MOUSE: Mus musculus; BD01_PIG: Sus scrofa (Pig); TAP_BOVIN: Bos taurus (Cow); BD01_SHEEP: Ovis aries (Sheep); BD01_CAPHI: Capra hircus (Goat). The net charge for each sequence is shown in the last column. Cationic residues are shown in italics, conserved positions are indicated with "*" if they are invariant and ":" if they are of similar polarity.

Human

G

I

G

D

P

V

T

C

L

K

S

G

A

I

C

H

P

V

F

C

P

R

R

Y

K

Q

I

G

T

C

G

L

P

G

T

K

C

C

K

K

P

+6

Chimp

G

I

S

D

P

V

T

C

L

K

S

G

A

I

C

H

P

V

F

C

P

R

R

Y

K

Q

I

G

T

C

G

L

P

G

T

K

C

C

K

K

P

+6

Monkey

G

I

G

D

P

V

T

C

L

K

N

G

A

I

C

H

P

V

F

C

P

R

R

Y

K

Q

I

G

T

C

G

L

P

G

T

K

C

C

K

K

P

+6

Pig

N

I

G

N

S

V

S

C

L

R

N

K

G

V

C

M

P

G

K

C

A

P

K

M

K

Q

I

G

T

C

G

M

P

Q

V

K

C

C

K

R

K

+9

Cow

G

V

G

N

P

V

S

C

V

R

N

K

G

I

C

V

P

I

R

C

P

G

S

M

K

Q

I

G

T

C

V

G

R

A

V

K

C

C

R

K

K

+9

Sheep

G

V

R

N

R

L

S

C

H

R

N

K

G

V

C

V

P

S

R

C

P

R

H

M

R

Q

I

G

T

C

R

G

P

P

V

K

C

C

R

K

K

+12

Goat

G

I

R

S

R

R

S

C

H

R

N

K

G

V

C

A

L

T

R

C

P

R

N

M

R

Q

I

G

T

C

F

G

P

P

V

K

C

C

R

K

K

+12

Rat

S

I

N

N

P

I

T

C

L

T

K

G

G

V

C

W

G

-

P

C

T

G

G

F

R

Q

I

G

T

C

G

L

P

R

V

R

C

C

K

K

K

+7

Mouse

K

I

N

N

P

V

S

C

L

R

K

G

G

R

C

w

N

-

R

C

I

G

N

T

R

Q

I

G

S

C

G

V

P

F

L

K

C

C

K

R

K

+10

:

.

:

*

.

.

*

*

:

*

*

*

:

*

:

*

*

:

:

Charge