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. 2000 Nov 21;97(25):13743–13748. doi: 10.1073/pnas.240465597

Figure 2.

Figure 2

Polypeptide sequence alignments of regions of LeuRS that contain splicing-sensitive elements. (A) CP1 region. The conserved boxed G is the location of the G288S splicing suppressor (3, 6). The conserved boxed W is the location of the W286C substitution that abolishes splicing activity (11). (B) C-terminal region. The two eukaryotic cytoplasmic enzymes contain a C-terminal extension of approximately 75 residues that is not shown. Abbreviations: Mt-1, M. tuberculosis (reported herein); Mt-2, GenBank accession no. 2501027; Ml, M. leprae; Bs, B. subtilis; Ec, E. coli; Scm, S. cerevisiae mitochondrial; Ncm, N. crassa mitochondrial; Hsm, Homo sapiens mitochondrial; Scc, S. cerevisiae-cytoplasmic; Ncc, N. crassa cytoplasmic.