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. Author manuscript; available in PMC: 2007 Dec 22.
Published in final edited form as: Biochem Biophys Res Commun. 2006 Oct 30;351(3):784–790. doi: 10.1016/j.bbrc.2006.10.116

Fig. 4.

Fig. 4

PKCɛ is involved in hypoxia-induced increase in [Ca2+]i in freshly isolated mouse resistance PASMCs. (A): PKCɛ translocation inhibitory peptide (10 μM) reduced hypoxia-induced increase in [Ca2+]i, whereas GÖ6976 (1 00 nM) had no effect. Data are presented as means ± SE from 18 cells in 5 independent experiments. *P < 0.05 compared with control (hypoxia alone). (B): Original recordings show hypoxia-induced increase in [Ca2+]i in a control (PKCɛ+/+) and PKCɛ gene deletion (PKCɛ−/−) PASMC. (C): Summary of the effect of PKCɛ gene deletion on hypoxic increase in [Ca2+]i. Data are presented as means ± SE from 23 cells in 4 independent experiments. *P < 0.05 compared with control (PKCɛ+/+).