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Schematic representation of aging-associated processes and connections between the FI and declining stress-resistance. The continuous (dashed) line depicts the more healthy, HS, (less healthy, DG) individuals at younger ages. Dashed-dotted line denotes the impact of the allostatic load (proportional to the FI) on stress-resistance. Increments in the FI (ΔFI) are proportional to the stress-load. See text for discussion.
