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. 2007 Jan 17;2(1):e156. doi: 10.1371/journal.pone.0000156

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Lee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Western blot analysis of apoptosis-related proteins, including proapoptotic proteins, (caspase 3 and Bax), antiapoptotic proteins (Bcl-2 and Bcl-X_L), and cell survival signal molecules (PI3-kinase p85, PI3 kinase p110 and Akt1) in ICH brains receiving transplantationof F3 and F3.VEGF human neural stem cells. A significantly decreased expression of caspase 3 and bax is found in ICH-F3.VEGF group at 2 and 8 weeks post-transplantation. In ICH animals receiving F3.VEGF grafts, the expression of antiapototic proteins and signal molecules Bcl-2, Bcl-X_L, PI3-K p85, PI3-K p110 and Akt1 is markedly increased.