Table 4.

CES-D: Sensitivity analysis (SA) of 0–12 month outcomes

Analysis	N	0 months		12 months		0–12 month difference
		Mean	SD	Mean	SD	Mean	SD	P-value	Median difference (95%-CI)
All patients enrolled in depression study
Main analysis: enrolled patients with evaluable data at 0 and 12 months	75	34.77	(8.21)	19.55	(13.12)	15.23	(12.72)	p < 0.001	15.50 (12.50–18.50)
SA1: last value carried forward	93	34.67	(7.95)	20.77	(12.56)	13.90	(12.29)	p < 0.001	15.00 (12.00–17.50)
SA2: Patients with a disease duration of ≥ 24 months	61	35.10	(8.25)	21.05	(13.53)	14.05	(13.07)	p < 0.001	14.50 (10.50–17.50)
SA3 Patients not using antidepressants or psychotherapy	39	33.03	(6.98)	17.74	(12.50)	15.29	(10.80)	p < 0.001	15.50 (12.00–19.00)
SA1+SA2+SA3	33	33.27	(6.88)	19.33	(13.16)	13.94	(11.85)	p < 0.001	14.00 (10.00–18.00)
AMOS patients screened for depression study after 1 Jan 2000*
Main analysis: enrolled patients with evaluable data at 0 and 12 months	37	33.65	(7.64)	20.27	(13.07)	13.38	(11.98)	p < 0.001	14.50 (9.50–17.50)
SA4: all screened patients (not enrolled + enrolled) with evaluable data at 0 and 12 months	57	28.35	(11.25)	18.53	(12.36)	9.82	(13.53)	p < 0.001	10.00 (6.50–14.00)
SA1+SA2+SA4	58	29.36	(10.51)	20.72	(12.03)	8.64	(12.46)	p < 0.001	9.50 (6.00–13.00)

CES-D: Center for Epidemiological Studies Depression Scale, German version. AMOS: Anthroposophic Medicine Outcomes Study. *12-month follow-up documentation of CES-D was not performed for AMOS patients enrolled before 1 Jan 2000, except for patients also enrolled into depression study. **Percentage of patients improved from baseline. SRM: Standardised Response Mean effect size (small: 0.20–0.49, medium: 0.50–0.79, large: ≥ 0.80)