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. 2007 Jan 24;2(1):e166. doi: 10.1371/journal.pone.0000166

Table 1. Clinical characteristics of the 13 grafted patients tested for the presence of antibodies against foetal donors' HLA I antigens.

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Patient 1 2 3 4 5 6 7 8 9 10 11 12 13
Disease duration (y) 11 8 5 6 9 9 7 7 7 5 4 4 6
TFC 10 10 11 11 9 7 10 13 8 9 10 12 13
UHDRS 55 61 28 36 37 64 32 23 64 26 50 28 15
MDRS 111 120 125 124 122 133 122 143 127 122 135 132 139
AC HLA I + + + + +
Cyclosporin A (m) 9 13 9 9 6 7 7 7 ongoing ongoing 6 6 ongoing
Imurel/solupred (m) 13 12 10 12 12 17 12 8 ongoing ongoing ongoing 12 ongoing
Adverse effects sdh Rejection inf sdh

Results of evaluation scales for general capacity (TFC, total functional capacitance), motor symptoms (UHDRS, motor part of the Unified Huntington Disease Rating Scale) and cognitive functions (MDRS, Mattis Dementia Rating Scale) are indicated at the time of grafting. The situation of the immunosuppressive treatment is indicated at the time of analysis of antibodies, either in months (m) when they have been interrupted according to the protocol (see text), or else as “ongoing”. Serious adverse effects besides rejection (patient 3, in bold) were subdural hematomas (sdh, in two cases) and cerebral infection (inf, 1 case). For sake of anonymity, individual patients' age, sex and number of CAG repeats are not shown. They were all between 39 and 55 years of age at the time of grafting; there were 5 women and 8 men; CAG repeats ranged between 42 and 49.