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Control of mixing can lead to control of nucleation in protein crystallization. (a) Schematic illustration of the plug-based microfluidic setup for studying the effect of mixing on the nucleation of protein crystals. Mixing by chaotic advection is illustrated. Microphotographs showing an example of the effect of (b) slow chaotic mixing and (c) fast chaotic mixing on protein crystallization under otherwise identical conditions. The diameter of the receiving capillary is 200 μm.
