Table 4.
Stratified relative risks (RRs) and 95% confidence intervals (CIs) for associations between wine intake in the year before baseline and risk of ovarian cancer within participant subgroups
| Characteristic (at baseline) | Alcohol consumption from wine | Ptrend | Pheterogeneity between subgroups | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| None | < 11.1 g/day | ≥ 11.1 g/day | ||||||||
| Cases | RRa | Cases | RRa | (95% CI)a | Cases | RRa | (95% CI)a | |||
| Age | ||||||||||
| ≤Median (50 years) | 23 | 1.00 | 27 | 1.07 | (0.58, 1.99) | 12 | 1.43 | (0.67, 3.04) | 0.34 | |
| >Median | 68 | 1.00 | 72 | 1.10 | (0.76, 1.57) | 51 | 1.62 | (1.09, 2.39) | 0.01 | 0.95 |
| Parity | ||||||||||
| Nulliparous | 18 | 1.00 | 26 | 1.34 | (0.69, 2.62) | 13 | 1.56 | (0.71, 3.40) | 0.31 | |
| Parous | 71 | 1.00 | 73 | 1.05 | (0.73, 1.50) | 48 | 1.57 | (1.06, 2.34) | 0.02 | 0.61 |
| Oral contraceptive use | ||||||||||
| Never | 45 | 1.00 | 39 | 1.00 | (0.62, 1.61) | 29 | 1.70 | (1.02, 2.82) | 0.03 | |
| Ever | 22 | 1.00 | 14 | 0.76 | (0.37, 1.58) | 14 | 1.78 | (0.85, 3.72) | 0.09 | 0.54 |
| Lifetime strenuous physical activity | ||||||||||
| ≤Median (1.4 hours/week) | 61 | 1.00 | 58 | 1.07 | (0.72, 1.59) | 40 | 1.68 | (1.09, 2.59) | 0.01 | |
| >Median (1.4 hours/week) | 30 | 1.00 | 41 | 1.11 | (0.66, 1.86) | 23 | 1.39 | (0.77, 2.50) | 0.26 | 0.55 |
| Menopausal status | ||||||||||
| Pre-menopausal | 21 | 1.00 | 20 | 0.83 | (0.42, 1.65) | 10 | 1.24 | (0.55, 2.83) | 0.53 | |
| Peri-/Post-menopausal | 66 | 1.00 | 72 | 1.16 | (0.80, 1.66) | 51 | 1.72 | (1.16, 2.55) | 0.01 | 0.86 |
| Hormone therapy (HT) use | ||||||||||
| Noneb | 21 | 1.00 | 22 | 1.27 | (0.64, 2.51) | 9 | 1.20 | (0.51, 2.78) | 0.73 | |
| Combination estrogen + progestin HTb | 23 | 1.00 | 18 | 0.69 | (0.35, 1.37) | 16 | 1.17 | (0.58, 2.34) | 0.45 | |
| Estrogen-only HTb | 16 | 1.00 | 19 | 1.27 | (0.62, 2.61) | 15 | 2.03 | (0.95, 4.35) | 0.06 | 0.37 |
| Region of residence | ||||||||||
| Greater Bay/Southern Coastal regions | 45 | 1.00 | 62 | 1.20 | (0.79, 1.84) | 38 | 1.69 | (1.06, 2.71) | 0.02 | |
| Other California regions | 46 | 1.00 | 37 | 0.94 | (0.59, 1.52) | 25 | 1.46 | (0.87, 2.48) | 0.12 | 0.41 |
| Type of residence | ||||||||||
| Rural/town/small city | 35 | 1.00 | 34 | 1.23 | (0.74, 2.06) | 23 | 1.77 | (1.01, 3.11) | 0.05 | |
| Metropolitan suburban/urban | 54 | 1.00 | 65 | 1.04 | (0.70, 1.55) | 40 | 1.51 | (0.97, 2.37) | 0.05 | 0.77 |
| Statewide percentile of socioeconomic status in census block groupc | ||||||||||
| Lower 75% | 57 | 1.00 | 50 | 1.09 | (0.72, 1.67) | 24 | 1.35 | (0.81, 2.27) | 0.25 | |
| Upper 25% | 32 | 1.00 | 49 | 1.16 | (0.72, 1.88) | 39 | 1.96 | (1.19, 3.24) | 0.004 | 0.43 |
| Body mass index | ||||||||||
| ≤Median (23.5 kg/m2) | 33 | 1.00 | 46 | 1.31 | (0.81, 2.11) | 32 | 1.64 | (0.97, 2.76) | 0.07 | |
| >Median | 53 | 1.00 | 52 | 0.97 | (0.63, 1.49) | 27 | 1.48 | (0.89, 2.45) | 0.10 | 0.69 |
| Cigarette smoking status | ||||||||||
| Never | 66 | 1.00 | 61 | 1.05 | (0.71, 1.56) | 36 | 1.77 | (1.13, 2.78) | 0.01 | |
| Ever | 25 | 1.00 | 38 | 1.19 | (0.69, 2.03) | 27 | 1.42 | (0.80, 2.50) | 0.24 | 0.57 |
| Dietary folate intake | ||||||||||
| ≤Median (307.1 μg/day)d | 23 | 1.00 | 21 | 0.73 | (0.37, 1.43) | 13 | 1.15 | (0.54, 2.44) | 0.55 | |
| >Mediand | 21 | 1.00 | 23 | 1.16 | (0.60, 2.24) | 10 | 1.17 | (0.51, 2.66) | 0.75 | 0.74 |
| Total folate intake | ||||||||||
| ≤Median (473.0 μg/day)e | 43 | 1.00 | 46 | 1.07 | (0.68, 1.70) | 25 | 1.34 | (0.78, 2.30) | 0.27 | |
| >Mediane | 41 | 1.00 | 48 | 1.20 | (0.77, 1.89) | 37 | 2.07 | (1.29, 3.35) | 0.002 | 0.43 |
a Adjusted for race, total energy intake, parity, oral contraceptive use, strenuous exercise, menopausal status/hormone therapy use, and consumption of beer and liquor in the past year; stratified by age at baseline
b Including peri-/post-menopausal women only
c See Methods for definition
d Excluding all multivitamin users (i.e., women consuming supplemental folate)
e Excluding short-term multivitamin users (i.e., women consuming supplemental folate for < 2 years)