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. Author manuscript; available in PMC: 2007 Jan 9.
Published in final edited form as: Curr Opin Chem Biol. 2006 May 3;10(3):226–231. doi: 10.1016/j.cbpa.2006.04.004

Figure 1.

Figure 1

A comparison of screening in microtiter plates and screening with preloaded cartridges. (a) To set up the screen in microtiter plates, robotics is required to dispense nanoliters of both the reagents and the substrate. Solutions in the microwells may evaporate. (b) With preloaded cartridges, the reagents are confined in nanoliter plugs. When the flow is induced, defined nanoliter aliquots of the substrate solution are spontaneously dispensed into the plugs of reagents. Plugs of the reagents and the products are confined in capillaries and are surrounded by an impermeable fluorinated carrier fluid, preventing evaporation.