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Thrombosis in cremaster arterioles after laser-induced injury in wild-type and Par4−/− mice. Shown are digital fluorescence and brightfield images of representative thrombi in a wild-type (Upper) and a Par4−/− (Lower) mouse at 5, 16, 74, 180, and 300 s after laser-induced injury of the blood vessel wall. Platelets were labeled with anti-mouse CD41 Fab fragments conjugated to Alexa-488. Red pseudo color, platelets.
