Fig. 5.

Tissue reactions in region of occluded penetrating arteriole. Sagittal section series taken across a 2.2-mm span centered on the fluorescent vessels that demarcate the core territory of the clotted arteriole (A2′, inverted image). These sections relate to the experiment that gave rise to the large dots in Fig. 3B. (A) Sections stained to localize tissue hypoxia demonstrate a confined high-density of staining at the level of the center of this series. The location of the clot is confirmed by trapped fluorescein/dextran (A2′). (B) Sections stained for immunoreactivity to IgG illustrate that vessel leakiness (B1′, B2′, and B3′) is concentrated at the center of this series (B2) yet extends up to 1.1 mm in medial and lateral directions.