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Exogenous RA disrupts cyp26b1 and cyp26c1 expression in cyp26a1-/- embryos but not in wild-type.
Cyp26b1 (A-D) and cyp26c1 (E-H) expression is established normally in wild-type (A,E) and cyp26a1-/- (B,F) embryos at the 6-somite stage (12 hpf). Cyp26b1 and cyp26c1 expression is also established normally in wild-type embryos treated with a sub-teratogenic concentration of RA (5 nM; C,G), but not in cyp26a1-/- embryos treated with 5 nM RA (D,H).
