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cyp26a1 protects against teratogenic effects of the RA precursor retinal.
Wild-type (A) and cyp26a1-/- (B) embryos injected with 18 pmol retinal at the 1-cell stage. Wild-type embryos are only mildly affected by approximately triple the normal levels of retinal, while cyp26 mutants are strongly posteriorized, with hoxd4 expression extending throughout the brain. Scale bar: 100 μm.
