Skip to main content
PMC home page
Thorax logoLink to Thorax
. 2000 Oct;55(Suppl 2):S38–S41. doi: 10.1136/thorax.55.suppl_2.S38

Lipoxins and other arachidonate derived mediators in bronchial asthma

C Chavis, I Vachier, P Godard, J Bousquet, P Chanez
PMCID: PMC1765959  PMID: 10992555

Full Text

The Full Text of this article is available as a PDF (92.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ang C., Clark E., Young I., Owe-Young R., Eyland A., Hunt J., Chesterman C., Krilis S. 15-hydroxyeicosatetraenoic acid synthesis from exogenous arachidonate by bronchial mucosa. J Lipid Mediat. 1990 Sep-Oct;2(5):263–269. [PubMed] [Google Scholar]
  2. Borgeat P. Biochemistry of the lipoxygenase pathways in neutrophils. Can J Physiol Pharmacol. 1989 Aug;67(8):936–942. doi: 10.1139/y89-147. [DOI] [PubMed] [Google Scholar]
  3. Brezinski D. A., Serhan C. N. Characterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: formation of lipoxin A4 by stimulated human whole blood. Biol Mass Spectrom. 1991 Feb;20(2):45–52. doi: 10.1002/bms.1200200202. [DOI] [PubMed] [Google Scholar]
  4. Chavis C., Godard P., Crastes de Paulet A., Damon M. Formation of lipoxins and leukotrienes by human alveolar macrophages incubated with 15(S)-HETE: a model for cellular cooperation between macrophages and airway epithelial cells. Eicosanoids. 1992;5(3-4):203–211. [PubMed] [Google Scholar]
  5. Chavis C., Godard P., Michel F. B., Crastes de Paulet A., Damon M. Sulfidopeptide leukotrienes contribute to human alveolar macrophage activation in asthma. Prostaglandins Leukot Essent Fatty Acids. 1991 Feb;42(2):95–100. doi: 10.1016/0952-3278(91)90074-f. [DOI] [PubMed] [Google Scholar]
  6. Chavis C., Vachier I., Bousquet J., Godard P., Chanez P. Generation of eicosanoids from 15(S)-hydroxyeicosatetraenoic acid in blood monocytes from steroid-dependent asthmatic patients. Biochem Pharmacol. 1998 Aug 15;56(4):535–541. doi: 10.1016/s0006-2952(98)00086-0. [DOI] [PubMed] [Google Scholar]
  7. Chavis C., Vachier I., Chanez P., Bousquet J., Godard P. 5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors. J Exp Med. 1996 Apr 1;183(4):1633–1643. doi: 10.1084/jem.183.4.1633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Christie P. E., Spur B. W., Lee T. H. The effects of lipoxin A4 on airway responses in asthmatic subjects. Am Rev Respir Dis. 1992 Jun;145(6):1281–1284. doi: 10.1164/ajrccm/145.6.1281. [DOI] [PubMed] [Google Scholar]
  9. De Caterina R., Sicari R., Giannessi D., Paggiaro P. L., Paoletti P., Lazzerini G., Bernini W., Solito E., Parente L. Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids. J Appl Physiol (1985) 1993 Dec;75(6):2368–2375. doi: 10.1152/jappl.1993.75.6.2368. [DOI] [PubMed] [Google Scholar]
  10. Diamond P., McGinty A., Sugrue D., Brady H. R., Godson C. Regulation of leukocyte trafficking by lipoxins. Clin Chem Lab Med. 1999 Mar;37(3):293–297. doi: 10.1515/CCLM.1999.051. [DOI] [PubMed] [Google Scholar]
  11. Edenius C., Kumlin M., Björk T., Anggård A., Lindgren J. A. Lipoxin formation in human nasal polyps and bronchial tissue. FEBS Lett. 1990 Oct 15;272(1-2):25–28. doi: 10.1016/0014-5793(90)80440-t. [DOI] [PubMed] [Google Scholar]
  12. Fiore S., Serhan C. N. Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J Exp Med. 1990 Nov 1;172(5):1451–1457. doi: 10.1084/jem.172.5.1451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Freeland H. S., Pipkorn U., Schleimer R. P., Bascom R., Lichtenstein L. M., Naclerio R. M., Peters S. P. Leukotriene B4 as a mediator of early and late reactions to antigen in humans: the effect of systemic glucocorticoid treatment in vivo. J Allergy Clin Immunol. 1989 Mar;83(3):634–642. doi: 10.1016/0091-6749(89)90076-6. [DOI] [PubMed] [Google Scholar]
  14. Godard P., Clot J., Jonquet O., Bousquet J., Michel F. B. Lymphocyte subpopulations in bronchoalveolar lavages of patients with sarcoidosis and hypersensitivity pneumonitis. Chest. 1981 Oct;80(4):447–452. doi: 10.1378/chest.80.4.447. [DOI] [PubMed] [Google Scholar]
  15. Hunter J. A., Finkbeiner W. E., Nadel J. A., Goetzl E. J., Holtzman M. J. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A. 1985 Jul;82(14):4633–4637. doi: 10.1073/pnas.82.14.4633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kim S. J. Formation of lipoxins by alveolar macrophages. Biochem Biophys Res Commun. 1988 Jan 29;150(2):870–876. doi: 10.1016/0006-291x(88)90473-1. [DOI] [PubMed] [Google Scholar]
  17. Kumlin M., Hamberg M., Granström E., Björck T., Dahlén B., Matsuda H., Zetterström O., Dahlén S. E. 15(S)-hydroxyeicosatetraenoic acid is the major arachidonic acid metabolite in human bronchi: association with airway epithelium. Arch Biochem Biophys. 1990 Nov 1;282(2):254–262. doi: 10.1016/0003-9861(90)90114-e. [DOI] [PubMed] [Google Scholar]
  18. Lam S., Chan H., LeRiche J. C., Chan-Yeung M., Salari H. Release of leukotrienes in patients with bronchial asthma. J Allergy Clin Immunol. 1988 Apr;81(4):711–717. doi: 10.1016/0091-6749(88)91043-3. [DOI] [PubMed] [Google Scholar]
  19. Lee T. H., Arm J. Leukotrienes. Allergy Proc. 1991 May-Jun;12(3):139–142. doi: 10.2500/108854191778879511. [DOI] [PubMed] [Google Scholar]
  20. Lee T. H., Crea A. E., Gant V., Spur B. W., Marron B. E., Nicolaou K. C., Reardon E., Brezinski M., Serhan C. N. Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. Am Rev Respir Dis. 1990 Jun;141(6):1453–1458. doi: 10.1164/ajrccm/141.6.1453. [DOI] [PubMed] [Google Scholar]
  21. Levy B. D., Romano M., Chapman H. A., Reilly J. J., Drazen J., Serhan C. N. Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest. 1993 Sep;92(3):1572–1579. doi: 10.1172/JCI116738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Linden M. The effects of beta 2-adrenoceptor agonists and a corticosteroid, budesonide, on the secretion of inflammatory mediators from monocytes. Br J Pharmacol. 1992 Sep;107(1):156–160. doi: 10.1111/j.1476-5381.1992.tb14479.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. López S., Vila L., Breviario F., de Castellarnau C. Interleukin-1 increases 15-hydroxyeicosatetraenoic acid formation in cultured human endothelial cells. Biochim Biophys Acta. 1993 Sep 29;1170(1):17–24. doi: 10.1016/0005-2760(93)90170-e. [DOI] [PubMed] [Google Scholar]
  24. Riddick C. A., Ring W. L., Baker J. R., Hodulik C. R., Bigby T. D. Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells. Eur J Biochem. 1997 May 15;246(1):112–118. doi: 10.1111/j.1432-1033.1997.00112.x. [DOI] [PubMed] [Google Scholar]
  25. Serhan C. N., Hamberg M., Samuelsson B., Morris J., Wishka D. G. On the stereochemistry and biosynthesis of lipoxin B. Proc Natl Acad Sci U S A. 1986 Apr;83(7):1983–1987. doi: 10.1073/pnas.83.7.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Serhan C. N., Hamberg M., Samuelsson B. Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. Biochem Biophys Res Commun. 1984 Feb 14;118(3):943–949. doi: 10.1016/0006-291x(84)91486-4. [DOI] [PubMed] [Google Scholar]
  27. Serhan C. N. On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. Biochim Biophys Acta. 1989 Aug 8;1004(2):158–168. doi: 10.1016/0005-2760(89)90264-6. [DOI] [PubMed] [Google Scholar]
  28. Serhan C. N., Takano T., Gronert K., Chiang N., Clish C. B. Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. Clin Chem Lab Med. 1999 Mar;37(3):299–309. doi: 10.1515/CCLM.1999.052. [DOI] [PubMed] [Google Scholar]
  29. Stahl G. L., Morse D. S., Martin S. L. Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. Am J Physiol. 1997 Jun;272(6 Pt 1):C1821–C1828. doi: 10.1152/ajpcell.1997.272.6.C1821. [DOI] [PubMed] [Google Scholar]
  30. Stenke L., Mansour M., Edenius C., Reizenstein P., Lindgren J. A. Formation and proliferative effects of lipoxins in human bone marrow. Biochem Biophys Res Commun. 1991 Oct 15;180(1):255–261. doi: 10.1016/s0006-291x(05)81285-9. [DOI] [PubMed] [Google Scholar]
  31. Thomas E., Leroux J. L., Blotman F., Chavis C. Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis. Inflamm Res. 1995 Mar;44(3):121–124. doi: 10.1007/BF01782022. [DOI] [PubMed] [Google Scholar]
  32. Uz T., Dwivedi Y., Savani P. D., Impagnatiello F., Pandey G., Manev H. Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain. J Neurochem. 1999 Aug;73(2):693–699. doi: 10.1046/j.1471-4159.1999.0730693.x. [DOI] [PubMed] [Google Scholar]
  33. Wenzel S. E., Larsen G. L., Johnston K., Voelkel N. F., Westcott J. Y. Elevated levels of leukotriene C4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis. 1990 Jul;142(1):112–119. doi: 10.1164/ajrccm/142.1.112. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES