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. 2000 Nov 21;97(25):13824–13829. doi: 10.1073/pnas.240303097

Figure 3.

Figure 3

Induction of the anagen progression by topical application of PMA in Stat3+/+ and Stat3−/− mice. Percutaneous treatment with PMA was made from PND 38. PMA (13.4 μg) in acetone was applied on the back skin five times in the first week and then twice weekly. Approximately 2 weeks later, newly formed hair emerged in both Stat3+/+ and Stat−/− mice, appearing in islands or patches (B, arrows), whose histology showed the anagen stage (A, 18 days of PMA application, PND 56). After 27 days of application (PND 65), follicles in both Stat3+/+ and Stat3−/− mice were at late anagen stage. During the observation period, Stat3+/+ and Stat3−/− mice in the acetone control group remained in telogen (A Top and third row), and hence no hair emerged (B). (Bar = 300 μm.)