Table 2.
Postmortem analysis of mice subjected to pressure overload
Data measure | Ntg mice |
dnPI3K mice |
caPI3K mice |
|||
---|---|---|---|---|---|---|
Sham (n = 7) | Band (n = 6) | Sham (n = 5) | Band (n = 6) | Sham (n = 5) | Band (n = 5) | |
Age, days | 134 ± 23 | 122 ± 13 | 153 ± 16 | 140 ± 18 | 123 ± 23 | 141 ± 8 |
BW, g | 29.5 ± 0.6 | 27.2 ± 1.5 | 29.4 ± 0.9 | 26.6 ± 1.2 | 28.4 ± 0.8 | 30.5 ± 1.0 |
HW, mg | 127.1 ± 4.2 | 164.0 ± 7.6* | 101.1 ± 3.6† | 166.0 ± 10.2*† | 148.0 ± 3.7† | 185.1 ± 5.0†‡ |
TL, mm | 16.8 ± 0.1 | 16.6 ± 0.1 | 17.1 ± 0.1 | 16.8 ± 0.1‡ | 16.8 ± 0.1 | 17.3 ± 0.1‡ |
HW/BW, mg/g | 4.31 ± 0.12 | 6.09 ± 0.34* | 3.44 ± 0.04† | 6.27 ± 0.38*† | 5.21 ± 0.08† | 6.07 ± 0.10†‡ |
HW/TL, mg/mm | 7.55 ± 0.25 | 9.85 ± 0.41* | 5.90 ± 0.19† | 9.90 ± 0.57* | 8.82 ± 0.20† | 10.67 ± 0.27†‡ |
nHW/BW | 1.00 ± 0.03 | 1.41 ± 0.08* | 0.80 ± 0.01† | 1.46 ± 0.09*† | 1.21 ± 0.02† | 1.41 ± 0.02†‡ |
nHW/TL | 1.00 ± 0.09 | 1.31 ± 0.05* | 0.78 ± 0.03† | 1.31 ± 0.08*† | 1.17 ± 0.03† | 1.41 ± 0.04†‡ |
% increase in HW/BW (compared with sham from same genotype) | 41 ± 8 | 82 ± 11§ | 17 ± 2§¶ | |||
% increase in HW/TL (compared with sham from same genotype) | 31 ± 5 | 68 ± 10§ | 21 ± 3¶ | |||
LW/BW, mg/g | 5.63 ± 0.22 | 8.20 ± 1.15‡ | 6.00 ± 0.25 | 9.94 ± 1.40‡ | 5.44 ± 0.31 | 7.34 ± 0.45¶ |
nHW/BW, normalized HW/BW (values normalized to Ntg sham); nHW/TL, normalized HW/TL (values normalized to Ntg sham); LW, lung weight.
*P < 0.0001 vs. sham of the same genotype.
†, P < 0.05 vs. Ntg sham.
‡, P < 0.05 vs. sham of the same genotype.
§, P < 0.05 vs. Ntg band.
¶, P < 0.05 vs. dnPI3K band.