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. 2007 Jan 3;104(2):612–617. doi: 10.1073/pnas.0606663104

Table 2.

Postmortem analysis of mice subjected to pressure overload

Data measure Ntg mice
dnPI3K mice
caPI3K mice
Sham (n = 7) Band (n = 6) Sham (n = 5) Band (n = 6) Sham (n = 5) Band (n = 5)
Age, days 134 ± 23 122 ± 13 153 ± 16 140 ± 18 123 ± 23 141 ± 8
BW, g 29.5 ± 0.6 27.2 ± 1.5 29.4 ± 0.9 26.6 ± 1.2 28.4 ± 0.8 30.5 ± 1.0
HW, mg 127.1 ± 4.2 164.0 ± 7.6* 101.1 ± 3.6 166.0 ± 10.2* 148.0 ± 3.7 185.1 ± 5.0
TL, mm 16.8 ± 0.1 16.6 ± 0.1 17.1 ± 0.1 16.8 ± 0.1 16.8 ± 0.1 17.3 ± 0.1
HW/BW, mg/g 4.31 ± 0.12 6.09 ± 0.34* 3.44 ± 0.04 6.27 ± 0.38* 5.21 ± 0.08 6.07 ± 0.10
HW/TL, mg/mm 7.55 ± 0.25 9.85 ± 0.41* 5.90 ± 0.19 9.90 ± 0.57* 8.82 ± 0.20 10.67 ± 0.27
nHW/BW 1.00 ± 0.03 1.41 ± 0.08* 0.80 ± 0.01 1.46 ± 0.09* 1.21 ± 0.02 1.41 ± 0.02
nHW/TL 1.00 ± 0.09 1.31 ± 0.05* 0.78 ± 0.03 1.31 ± 0.08* 1.17 ± 0.03 1.41 ± 0.04
% increase in HW/BW (compared with sham from same genotype) 41 ± 8 82 ± 11§ 17 ± 2§
% increase in HW/TL (compared with sham from same genotype) 31 ± 5 68 ± 10§ 21 ± 3
LW/BW, mg/g 5.63 ± 0.22 8.20 ± 1.15 6.00 ± 0.25 9.94 ± 1.40 5.44 ± 0.31 7.34 ± 0.45

nHW/BW, normalized HW/BW (values normalized to Ntg sham); nHW/TL, normalized HW/TL (values normalized to Ntg sham); LW, lung weight.

*P < 0.0001 vs. sham of the same genotype.

†, P < 0.05 vs. Ntg sham.

‡, P < 0.05 vs. sham of the same genotype.

§, P < 0.05 vs. Ntg band.

¶, P < 0.05 vs. dnPI3K band.