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. 2007 Jan 24;2(1):e167. doi: 10.1371/journal.pone.0000167

Figure 6. Activation of GluR5 in the BLA affected the output to the CeM in the amygdala.

Figure 6

(A) Diagram showing the placement of the stimulating electrode (Sti) and drug puff-application pipette (Puff) in the BLA as well as recording electrode (Rec) in the CeM (left). A typical late-firing neuron showed the delayed firing properties in respond to current steps that from −50 pA to 75 pA within 400 ms (right). Resting membrane potential for this neuron is −63.3 mV. Scale bar, 15 mV and 80 ms. Lower traces showing evoked responses in a CeM neuron by electric stimulation in the BLA. At holding potential of −45 mV, biphasic responses were observed and CNQX application could block both of them. At holding potential of −70 mV, only inward current was observed. (B) Typical recording and cumulative probability plot showing that ATPA (3 µM) application in the BLA decreased sEPSCs in a CeM late-firing neuron. Inset: Relative frequency (freq.) during ATPA application was significantly decreased (n = 6). (C) Typical traces showing that after puff application of ATPA (3 µM) in the BLA, eEPSCs recorded in a CeM neuron were decreased. (D) Individual experiments and statistical results showing that ATPA reduced eEPSC amplitude (n = 7, each neuron represented by a separate symbol). * P<0.05, **P<0.01.