Figure 2  .

Effect of infliximab on circulating IL6 measurements in a randomised placebo controlled trial of infliximab in RA. Patients were treated on day 0 with a single, two hour infusion of either placebo (circle), 1 mg/kg infliximab (diamond) or 10 mg/kg infliximab (triangle). A detailed time/response profile on day 0 and 1 is shown on the left, with the mean sampling times indicated on the figure. Changes in circulating IL6 in the same three patient groups over the longer term are shown on the right. Each point represents the median circulating IL6 (pg/ml) concentrations. * p < 0.05; ** p < 0.01; *** p < 0.001 compared with placebo by ANOVA. Reproduced from J Immunol 1999;163:1521−8 by kind permission of the editor.