Figure 3  .

Decreases in (A) serum E selectin concentration and (B) serum ICAM-1 concentration after infliximab infusion in a randomised placebo controlled trial of infliximab in RA. Patients were treated on day 0 with a single, two hour infusion of either placebo (circle), 1 mg/kg infliximab (diamond) or 10 mg/kg infliximab (triangle). Values are expressed relative to median pre-infusion values (100%) in placebo treated (n = 24), 1 mg/kg (n = 23) and 10 mg/kg (n = 21) of infliximab treated patients. Significance was determined versus change in placebo treated group at different time points by Mann-Whitney U test: † = p < 0.05; †† = p < 0.01; ††† = p < 0.001. Reproduced with modification from Arthritis Rheum 1996;39:1082-91 by kind permission of the editor.