Figure 4  .

Changes in circulating lymphocyte counts after infliximab infusion in a randomised placebo controlled trial of infliximab in RA. Values are the median counts in placebo treated (circle) (n = 24), 1 mg/kg (diamond) (n = 23) and 10 mg/kg (triangle) (n = 21) of infliximab treated patients. Circulating numbers of lymphocytes in patients with active RA were measured before and after treatment. Significance was versus change in placebo treated group at different time points by Mann-Whitney U test: † = p < 0.05; †† = p < 0.01; ††† = p < 0.001. Reproduced with modification from Arthritis Rheum 1996;39:1082-91 by kind permission of the editor.