Skip to main content
. 2002 Nov;61(Suppl 2):ii46–ii50. doi: 10.1136/ard.61.suppl_2.ii46

Figure 2 .

Figure 2

Inhibiton of C3 convertase ameliorates aPL-IgG induced pregnancy complications. Female BALB/c mice were treated ip with IgG (10 mg) from a patient with APS (aPL), normal human IgG (Cntrl IgG) or saline (Vehicle) on days 8 and 12 of pregnancy. Some of the mice received an inhibitor of C3 convertase, Crry-Ig (3 mg ip) every other day from days 8–12. Mice were killed on day 15 of pregnancy, uteri were dissected, fetuses were weighed, and frequency of fetal resorption calculated (number of resorptions/number of fetuses + number of resorptions). There were six mice in each group. (A) Treatment with aPL-IgG caused an increase in fetal resorptions compared with vehicle or control human IgG (*p<0.05), which was prevented by Crry-Ig (*aPL v aPL + Crry-Ig p<0.05). (B) aPL-IgG caused fetal growth retardation (*aPL v Cntrl IgG p<0.01), which was also prevented by Crry-Ig (*aPL v aPL + Crry-Ig p<0.01). Reproduced from the J Exp Med 2001;195:214 by copyright permission of The Rockefeller Press.