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. 2002 Nov;61(Suppl 2):ii25–ii28. doi: 10.1136/ard.61.suppl_2.ii25

Balancing the immune system: Th1 and Th2

W van Eden, R van der Zee, P van Kooten, S Berlo, P Cobelens, A Kavelaars, C Heijnen, B Prakken, S Roord, S Albani
PMCID: PMC1766722  PMID: 12379616

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Figure 1 .

Figure 1

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Three mechanisms of anti-inflammatory T cell induction by hsp. APL regulation: microbial hsp reactive T cells perceive self hsp homologues as partial agonists or APLs and develop a regulatory phenotype. Mucosal tolerance: hsp reactive T cells recognise microbial hsp in the tolerising GALT and display a tolerising activity when confronted with self hsp expressed elsewhere in the body. Anergy: non-professional or non-activated antigen presenting cells present constitutively self hsp in the absence of costimulation. The resulting self hsp specific "anergic" T cell can exert regulatory activity after the encounter with professional or activated APC presenting upregulated self hsp. Self hsp in lighter grey tone. Microbial hsp in darker grey tone.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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