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. Author manuscript; available in PMC: 2008 Jan 15.
Published in final edited form as: Bioorg Med Chem. 2006 Oct 25;15(2):1062–1066. doi: 10.1016/j.bmc.2006.10.022

Scheme 3.

Scheme 3

Reagents and conditions: (i) H3C(CH2)14C(O)Cl, F3CCO2H, 23°C, 20 min, then 40°C, 40 min, 91%; (ii) O(CO2tBu)2, NaH2O, 23°C, 15 h, 64%; (iii) tBuOH, (iPrHN=)2C, CuCl, 23°C, 12 h, then add 7 in CH2Cl2, 40°C, 48 h, 70%; (iv) NaOMe, MeOH, 1 h, 23°C, 71%.