Table 2.

Cardiac transplantation contraindication criteria

Cardiac disease	Irreversible pulmonary hypertension (PVR >6 WU despite standardised reversibility testing protocol)
Other diseases	Active infection
	Pulmonary infarction within the last 6–8 weeks
	Significant chronic renal impairment with persistent creatine >2.5 or clearance <25 ml/min
	Significant chronic hepatic impairment with persistent bilirubin >2.5 or ALT/AST >×2
	Active or recent malignancy
	Systemic diseases such as amyloidosis
	Significant chronic lung disease
	Significant symptomatic carotid or peripheral vascular disease
	Significant coagulopathies
	Recent peptic ulcer disease
	Major chronic disabling disease
	Diabetes with end organ damage and/or brittle diabetes
	Excessive obesity (e.g. >30% over normal)
Psychosocial	Active mental illness
	Evidence of drug, tobacco, of alcohol abuse within the last six months refractory to expert intervention
	Psychosocial instability refractory to expert intervention
Age	> 65 years

ALT/AST, ratio of serum alanine aminotransferase to aspartate aminotransferase; PVR, pulmonary vascular resistance; WU woods units.