Table 5.

Effect of denervation on cardiac pharmacology

Substance	Effect on recipient	Mechanism
Digitalis	Normal increase of contractility; minimal effect on AV node	Direct myocardial effect; denervation
Atropine	None	Denervation
Adrenaline	Increased contractility; increased chronotropy	Denervation hypersensitivity
Noradrenaline	Increased contractility; increased chronotropy	Denervation hypersensitivity
Isoproterenol	Normal increase in contractility; normal increase in chronotropy	No neuronal uptake
Quinidine	No vagolytic effect	Denervation
Verapamil	AV block	Direct effect
Nifedipine	No reflex tachycardia	Denervation
Hydralazine	No reflex tachycardia	Denervation
β Blocker	Increased antagonist effect	Denervation

AV, atrioventricular.