Figure 1.

Pedigree of a family with hypertrophic cardiomyopathy (HCM). In generations III to V only those confirmed to have the myosin binding protein C (MyBP-C) mutation are represented (n = 26). Filled symbols represent family members fulfilling conventional diagnostic criteria for HCM, partially filled symbols represent those fulfilling criteria for the diagnosis of HCM in the context of a family history, and open symbols represent gene carriers with no clinical features of HCM. Numbers of pro-left ventricular hypertrophy (LVH) genotypes detected in the person are shown. –, no pro-LVH renin-angiotensin-aldosterone genotype.